Le mot "cause" est fréquemment employé dans des publications scientifiques, parfois sans conscience claire de ce qu'il implique. Ce terme a une histoire philosophique au cours de laquelle sa signification et son usage dans les sciences ont été tantôt défendus, tantôt critiqués. D'une part la recherche de causes naturelles est bien constitutive du projet scientifique, d'autre part le terme de cause peut facilement véhiculer des conceptions naïves de la relation entre causes et effets, dont les conséquences peuvent être de retarder ou de mal orienter la recherche de facteurs de causalité. Les sciences biologiques et médicales sont riches d'exemples de ce type. Plusieurs questions peuvent être posées. Quelle est l'utilisation présente de la causalité dans les sciences biologiques et médicales ? Quelles sont les difficultés particulières liées à l'établissement des relations de causalité ? Comment ces difficultés peuvent-elles être surmontées ? L'identification de conditions causales permet-elle de prédire la succession de phénomènes physiologiques ? Est-il souhaitable de conserver le langage causaliste pour décrire des situations où règne le multifactoriel ? Comment mieux décrire ces situations par d'autres langages, et est-ce toujours possible ? Les textes réunis dans cet ouvrage sont pour la plupart issus du colloque "Faut-il connaître les causes pour comprendre et intervenir ? Questions sur la causalité dans les sciences biologiques et médicales", organisé le 31 mai 2016 par l'Académie des sciences, sur l'initiative de sa section de biologie humaine et sciences médicales.

Le praticien dispose d’un grand nombre de techniques d’imagerie et de tests de laboratoire qui lui permettent d’effectuer des examens poussés pour ses patients. Cependant, il faut resituer cet arsenal technique au sein d’une médecine globale, car tous ces moyens modernes et pointus n’ont pas diminué la proportion des erreurs médicales. Aujourd’hui encore, recueillir de façon exhaustive les antécédents et les symptômes du patient et procéder `un examen physique approfondi, sont les étapes préalables `une bonne prise en charge thérapeutique. « Partir du symptôme pour éviter l’erreur médicale », tel est le principe de cet ouvrage qui recense tous les symptômes que peut rencontrer le médecin dans sa pratique quotidienne.

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L'origine des douleurs dentaires remonte aux premières caries, il y a 5000 ans, quand l'homme a commencé à cuire les aliments. Cet ouvrage présente l'évolution de la prise en charge des douleurs et de sa perception, des techniques d'anesthésie-analgésie et la pharmacopée développée à travers les siècles.

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This user-friendly clinical handbook provides a clear and concise overview of how to recognize and diagnose inherited metabolic diseases. The reader is led through the diagnostic process from the identification of those features of an illness suggesting that it might be metabolic through the selection of appropriate laboratory investigation to a final diagnosis. The new edition provides more in-depth coverage on mitochondrial disease and congenital disorders of glycosylation. The chapters on neurological syndrome and newborn screening are greatly expanded, as well as those on laboratory investigation and treatment.

The field of muscular dystrophies has expanded significantly with the discovery of the genetic defects and protein products underlying these disorders. New treatments such as antisense oligonucleotides and siRNAs and gene therapies are now in clinical application and in trials. As clinical trials increase, outcome measurement becomes very important, and more validated tools are being developed. This book provides a comprehensive review of these disorders. Clinical features, diagnostic testing including genetic testing of these disorders, the basis and utility of genetic testing, and the basis of genetic therapies are all covered in detail. This book will provide neuromuscular neurologists, general neurologists, and neuromuscular fellows with a much needed update in the field.

The scope of the book includes all neurological problems in infancy. In the first half, it sets out in a succinct format the principles of working with families, of clinical assessment, of the use of investigations and treatments, and of evidence-based medicine. The second, symptom-based half of the book provides detailed guidance on the practice of child neurology in infancy. The authors are distinguished experts drawn from all over Europe. The contributors have approached their chapters using an accessible, didactic style and consistent organization of material. The emphasis throughout is on clinical methods, the use of appropriate investigations and treatments, and the avoidance of unnecessary or potentially harmful interventions. For quick reference, all chapters feature boxes highlighting key messages, common errors, and when to worry. The book is designed to be carried round as a handy reference.

Core Principles of Acute Neurology is a series of short volumes that handles major topics not found in sufficient detail elsewhere and provides useful context. Identifying Neuroemergencies provides practical information how to best manage and triage patients in the first hour of admission in the emergency department. Physicians consider a neurologic emergency when the patient has clearly worsened and their neurologic signs have changed. Correct decisions are imperative: any type of neurocritical illness demands immediate treatment in the emergency department. Neurologist can assist further with the successful triage of the neurologic emergency and this volume in the Core Principles of Acute Neurology will serve as a handy, concise, reference to both the neurologist and the emergency physician.

The definitive text on the full spectrum of neurology-50th Anniversary Edition! For 50 years the field’s gold-standard text, Adams and Victor’s Principles of Neurology provides up to date treatment and management strategies needed to confidently handle both common and rare neurologic conditions. Presented in full color, this enduring resource meets the needs of today’s aspiring clinician or seasoned professional, and has been hailed as the most detailed, thorough, and authoritative text on the subject. Adams and Victor’s Principles of Neurology, Twelfth Edition features: An evenness of style and a uniform approach to subject matter across subspecialties that allows a quick and easy review of each topic and condition Scholarly discussions that give readers a comprehensive overview of neurologic illnesses Unrivaled coverage of signs and symptoms Evidence based discussions of the full range of therapeutic options available to treat neurologic diseases, including drug therapy and rehabilitation methods Coverage of the most exciting discoveries from modern neuroscience that bear on and explain neurologic diseases and treatments More than 900 full-color, high-quality images and illustrations

The definitive guide to understanding, diagnosing, and treating neurologic disease – more complete, timely, and essential than ever