Over the past decades, advances in computing and information technology have led to massive datasets in fields ranging from medicine and biology to finance and marketing. Understanding and drawing insights from these data require more than traditional statistical tools giving rise to new methods in data mining, machine learning, and bioinformatics. This book brings together the key ideas from these areas under a unified, statistical framework. Rather than focusing on heavy mathematical derivations, the emphasis is on concepts, intuition, and practical understanding. Through numerous examples and plentiful four color graphics, the book aims to make complex methods accessible while retaining statistical rigor.